If you were a double bassist and I write a piece in which the double-basses' E string is detuned to the point that they nearly fall off, what reaction could I expect to get from the section?
Work on long tones. Maybe play a concert B-flat (C-D-E-F-G-A-B-C) or concert C (D-E-F#-G-A-B-C#-D) and hold each note for 2+ bars at 60 bpm before moving to the next one. This helped me build my chops for more consistent notes and a fuller tone.